Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7439)
STING1/TMEM173 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 면역조직화학(IHC)에 사용 가능. 단백질 A/G로 정제된 액상 항체이며, 인간 시료에 반응. STING 관련 선천면역 신호 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STING1/7439 |
| Immunogen | Recombinant fragment (around aa190–290) of human TMEM173 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
STING is a 379 amino acid signaling protein that plays a key role in innate immune signaling. It activates both NF-κB and IRF3 transcription pathways to induce type I interferons (IFN-α and IFN-β), establishing an antiviral state. STING may also function as a translocon influencing interferon induction and mediates apoptotic signaling through association with MHC-II. It is localized in the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane, and is ubiquitously expressed in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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