Thermo Fisher Scientific Glutamine Synthetase Recombinant Rabbit Monoclonal Antibody (7H9L16)
Glutamine Synthetase 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, Human, Mouse, Rat에 반응합니다. 단백질 A로 정제된 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7H9L16 |
| Immunogen | Protein corresponding to Human GLUL (aa 2–373) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633045 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, and Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays a central role in mammalian nitrogen flow, serving as both a nitrogen donor and acceptor.
It also plays an important role in regulating the metabolism of the neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are tightly regulated. The activity of GS is controlled by adenylylation and is decreased in the cerebral cortex of Alzheimer’s disease brains, particularly near senile plaques, as well as under glucose deprivation conditions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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