Thermo Fisher Scientific PDCD1LG2 Monoclonal Antibody (6G9)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ALFTVTVPKE LYIIEHGSNV TLECNFDTGS HVNLGAITAS LQKVENDTSP HRERATLLEE QLPLGKASFH IPQVQVRDEG QYQCIIIYGV AWDYKYLTLK VKA

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for programmed cell death protein 1 (PD-1). PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment.

PD-L2 expression increases in the presence of cytokines such as IL-4, TNF-α, and IFN-γ. Although expressed at lower levels than PD-L1, PD-L2 has a 2–6 times higher affinity to PD-1. PD-1 and its ligands serve as inhibitory immune checkpoint molecules that regulate immune homeostasis by inhibiting T-cell activation, proliferation, and cytokine secretion (e.g., IFN-γ, IL-10).

Interestingly, PD-L2 can also stimulate T-cell proliferation and cytokine production independently of PD-1, suggesting additional receptors. Recent studies identified repulsive guidance molecule b (RGMb) as a second receptor for PD-L2. Interaction between PD-L2 and RGMb contributes to respiratory tolerance regulation in the lung through BMP and/or neogenin signaling pathways.

The human PD-L2 monomer consists of:

• 201-amino-acid extracellular domain
• 21-amino-acid transmembrane domain
• 32-amino-acid cytoplasmic domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.