Thermo Fisher Scientific PDCD1LG2 Monoclonal Antibody (3B11)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ALFTVTVPKE LYIIEHGSNV TLECNFDTGS HVNLGAITAS LQKVENDTSP HRERATLLEE QLPLGKASFH IPQVQVRDEG QYQCIIIYGV AWDYKYLTLK VKASYRKINT HILKVPETDE VELTCQATGY PLAEVSWPNV SVPANTSHSR TPEGLYQVTS VLRLKPPPGR NFSCVFWNTH VRELTLASID LQSQMEPRTH PT

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, belongs to the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for PD-1. PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by IL-4 and to a lesser extent by TNF-alpha and IFN-gamma. PD-L2 has a higher affinity to PD-1 compared to PD-L1 and functions as an inhibitory immune checkpoint molecule, regulating T cell activation and cytokine secretion. Additionally, PD-L2 interacts with RGMb, influencing respiratory tolerance development through BMP and neogenin pathways. The human PD-L2 monomer comprises a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.