Thermo Fisher Scientific PDCD1LG2 Monoclonal Antibody (1F12)

Applications

• ELISA (ELISA)
  Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ALFTVTVPKE LYIIEHGSNV TLECNFDTGS HVNLGAITAS LQKVENDTSP HRERATLLEE QLPLGKASFH IPQVQVRDEG QYQCIIIYGV AWDYKYLTLK VKA

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for PD-1. PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by IL-4 and, to a lesser extent, TNF-alpha and IFN-gamma.
PD-L2 exhibits 2–6 times higher affinity for PD-1 compared to PD-L1. The PD-1/PD-L pathway functions as an inhibitory immune checkpoint regulating T cell activation, proliferation, and cytokine secretion. Interestingly, PD-L2 can also stimulate T cell responses independently of PD-1, suggesting additional receptors such as RGMb. PD-L2–RGMb interaction has been implicated in respiratory tolerance regulation through BMP/neogenin signaling pathways.
The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.