Thermo Fisher Scientific PDCD1LG2 Monoclonal Antibody (4D6)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ALFTVTVPKE LYIIEHGSNV TLECNFDTGS HVNLGAITAS LQKVENDTSP HRERATLLEE QLPLGKASFH IPQVQVRDEG QYQCIIIYGV AWDYKYLTLK VKA

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for PD-1. PD-L2 is expressed primarily in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Expression is upregulated by Th2 cytokine IL-4 and, to a lesser extent, by Th1 cytokines TNF-alpha and IFN-gamma.

PD-L2 binds PD-1 with a 2–6 times higher relative affinity than PD-L1 and functions as an inhibitory immune checkpoint molecule, providing negative feedback during immune homeostasis. Ligation of PD-L2 or PD-L1 inhibits T cell activation, proliferation, and cytokine secretion (e.g., IFN-gamma, IL-10). Interestingly, PD-L2 can also stimulate T cell proliferation and cytokine production even in PD-1-deficient T cells, suggesting additional receptors. Recent studies have identified RGMb (repulsive guidance molecule b) as a second receptor for PD-L2, which plays a role in respiratory tolerance through BMP and/or neogenin signaling pathways.

The human PD-L2 monomer consists of:

• 201 amino acids in the extracellular domain
• 21 amino acids in the transmembrane domain
• 32 amino acids in the cytoplasmic domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.