Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4723)
Clusterin/Apolipoprotein J 단백질을 인식하는 Thermo Fisher Scientific의 CLU/4723 단클론 항체로, 인간 시료에 반응하며 WB, IHC 등 다양한 응용에 사용 가능. Protein A/G로 정제된 액상 형태로, 보존제가 없으며 -20°C에서 보관.
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- 1191-MSM3-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLU/4723 |
| Immunogen | Recombinant fragment (around aa150–300) of human CLU protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). It maintains partially unfolded proteins for refolding by other chaperones such as HSPA8/HSC70. Secreted isoform 1 protects cells against apoptosis and complement-induced cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes, promoting ubiquitination and proteasomal degradation of target proteins, including COMMD1 and IKBKB, and modulate NF-kappa-B activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent cytochrome c release, inhibiting apoptosis and regulating cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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