Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4727)
Human Clusterin/Apolipoprotein J 단백질을 인식하는 mouse monoclonal antibody. Western blot 및 IHC 등 다양한 응용에 적합. Protein A/G 정제, 200 µg/mL 농도의 액상 형태. 4°C에서 보관, 동결 금지.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLU/4727 |
| Immunogen | Recombinant fragment (around aa150–300) of human CLU protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by several aggregation-prone proteins and maintains partially unfolded proteins for refolding by other chaperones such as HSPA8/HSC70. It does not refold proteins by itself but facilitates degradation of client proteins through lysosomal or proteasomal pathways after receptor-mediated internalization.
Secreted isoform 1 protects cells from apoptosis and complement-mediated cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes, promoting proteasomal degradation of target proteins such as COMMD1 and IKBKB, thereby modulating NF-κB transcriptional activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent cytochrome c release and inhibit apoptosis. Clusterin plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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