Thermo Fisher Scientific Phospho-53BP2 (Ser698) Polyclonal Antibody
Phospho-53BP2 (Ser698) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응합니다. Western blot에 적합하며, Ser698에서 인산화된 ASPP2를 특이적으로 검출합니다. 고순도 정제, PBS/glycerol 버퍼 저장, 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TP53BP2 (Accession Q13625), corresponding to amino acid residues around phosphorylated Ser698 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816543 |
Product Specific Information
Antibody detects endogenous levels of ASPP2 only when phosphorylated at Ser698.
Target Information
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions.
Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis.
Impedes cell cycle progression at G2/M.
Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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