Thermo Fisher Scientific Phospho-PHGDH (Thr78) Polyclonal Antibody
PHGDH 단백질의 Thr78 인산화 형태를 특이적으로 인식하는 rabbit polyclonal 항체. Western blot에 적합하며, 인간, 마우스, 랫트 시료에 반응. L-serine 생합성 연구 및 신경발달 관련 연구에 유용. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PHGDH (Accession O43175), corresponding to amino acid residues around phosphorylated Thr78. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816542 |
Product Specific Information
This antibody detects endogenous levels of PHGDH only when phosphorylated at Thr78.
Target Information
The PHGDH gene encodes an enzyme involved in the early steps of L-serine synthesis in animal cells.
L-serine is required for D-serine and other amino acid synthesis.
The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity.
Mutations in this gene have been associated with congenital microcephaly, psychomotor retardation, and other neurological symptoms.
Multiple alternatively spliced transcript variants have been identified, though the full-length nature of most remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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