Thermo Fisher Scientific Phospho-PHGDH (Thr78) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of PHGDH only when phosphorylated at Thr78.

Target Information

The PHGDH gene encodes an enzyme involved in the early steps of L-serine synthesis in animal cells.
L-serine is required for D-serine and other amino acid synthesis.
The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity.
Mutations in this gene have been associated with congenital microcephaly, psychomotor retardation, and other neurological symptoms.
Multiple alternatively spliced transcript variants have been identified, though the full-length nature of most remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.