Thermo Fisher Scientific Phospho-SOS1 (Ser1082) Polyclonal Antibody
인간, 마우스, 랫트에서 반응하는 SOS1 Ser1082 인산화 특이 토끼 폴리클로날 항체. Western blot에 적합하며, 세포 신호전달 연구용. 1 mg/mL 농도의 액상 형태로, -20°C 보관. 연구용 전용 제품.
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Thermo Fisher Scientific Phospho-SOS1 (Ser1082) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SOS1 (Accession Q07889), corresponding to amino acid residues around phosphorylated Ser1082 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816545 |
Product Specific Information
Antibody detects endogenous levels of SOS1 only when phosphorylated at Ser1082.
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1 and its closely related Sos2 paralog contain:
- N-terminal histone-binding domain
- RacGEF catalytic (DH) domain with PH domain
- Ras exchanger motif (REM) domain
- RasGEF catalytic domain
- C-terminal proline-rich region
Sos1 catalyzes GDP-GTP exchange within membrane-bound Ras, activating the MAPK cascade central to cellular proliferation, survival, and differentiation. Growth factor stimulation induces phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation within the Sos C-terminus by MAP/ERK kinase disrupts the Grb2-Sos complex.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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