Thermo Fisher Scientific Placental Alkaline Phosphatase Monoclonal Antibody (H7E8)
인간 태반 알칼리성 포스파타제(PLAP)를 인식하는 Mouse IgG2a 단일클론 항체로, WB, IHC, ELISA 등 다양한 응용에 적합합니다. 단백질 A로 정제된 액상 형태이며, PBS(pH 7.4) 버퍼에 15mM sodium azide를 포함합니다. 연구용으로만 사용됩니다.
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- MA119354
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H7E8 |
| Immunogen | Purified placental alkaline phosphatase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1086697 |
Product Specific Information
This antibody recognizes an extracellular epitope of trophoblast-derived membrane-associated enzyme alkaline phosphatase.
Target Information
Placental Alkaline Phosphatase (PLAP) plays an important role in regulating specific inflammatory disease processes. There are four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney types. PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) occurring in the placenta during the third trimester of gestation. It is useful in identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors express epithelial membrane antigen (EMA). A proposed function of PLAP is matrix mineralization; however, mice lacking functional PLAP show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects, with variable severity depending on mutation type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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