Thermo Fisher Scientific CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), PE, eBioscience
인간 Siglec-7 (CD328) 검출용 마우스 모노클로날 항체로, PE 형광 표지되어 NK 세포 및 골수세포의 발현 분석에 적합. Flow Cytometry에 최적화되어 있으며, 5 µL/test로 사용. 세포 증식 및 면역 반응 연구에 활용 가능.
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Thermo Fisher Scientific CD328 (Siglec7) Monoclonal Antibody (eBioQA79 (QA79)), PE, eBioscience
Applications and Tested Dilution
- Applications Reported: Flow Cytometry
- Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- Recommended Dilution: 5 µL (0.5 µg)/test
- Cell Range: 10⁵–10⁸ cells/test
Publications
- Flow Cytometry: View 1 publication
- Miscellaneous PubMed: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioQA79 (QA79) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL / Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11063982 |
Product Specific Information
The eBioQA79 monoclonal antibody reacts with adhesion inhibitory receptor molecule 1 (AIRM1), also known as sialic acid binding immunoglobulin-like lectin 7 (Siglec-7), p75, and CDw328.
AIRM1 is a cell surface receptor belonging to the sialoadhesin family and shows homology with CD33. Its expression is confined to NK cells and various stages of myeloid differentiation. Crosslinking with eBioQA79 inhibits NK function.
This antibody is useful for monitoring cellular proliferation, particularly in conditions such as chronic myeloid leukemia.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Siglec-7 is a putative adhesion molecule mediating sialic acid-dependent binding to cells. It preferentially binds alpha-2,3- and alpha-2,6-linked sialic acids and disialogangliosides.
Its recognition site may be masked by cis interactions on the same cell surface.
In immune response, Siglec-7 acts as an inhibitory receptor via ligand-induced tyrosine phosphorylation, recruiting phosphatases that block signal transduction.
It mediates inhibition of NK cell cytotoxicity and may play roles in hemopoiesis and leukemic myeloid cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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