Thermo Fisher Scientific IDO Monoclonal Antibody (V1NC3IDO), eFluor 660, eBioscience
인간 IDO1을 특이적으로 인식하는 V1NC3IDO 단클론 항체로, eFluor 660 형광 표지로 적색 레이저(633 nm) 검출에 최적화됨. IHC 및 ICC/IF에 사용 가능하며, IDO2와 교차 반응 없음. 연구용으로 면역조절 및 종양 연구에 적합.
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- pk
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Thermo Fisher Scientific IDO Monoclonal Antibody (V1NC3IDO), eFluor 660, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 20 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | V1NC3IDO |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574357 |
Additional Formats
Product Specific Information
The monoclonal antibody V1NC3IDO recognizes human IDO1 (indoleamine-2,3-dioxygenase).
IDO1 is an intracellular enzyme that catalyzes the degradation of tryptophan to kynurenines.
It is expressed in various tissues and cells, including macrophages, plasmacytoid dendritic cells, and several cell lines.
IDO1 can be induced by IFN-γ or other inflammatory stimuli.
Expression of IDO1 in antigen-presenting cells and tumors mediates immune suppression through tryptophan depletion and production of metabolites that induce T cell apoptosis and regulatory T cells.
This antibody reacts with IDO1 and does not cross-react with IDO2.
Applications Reported: Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections.
Applications Tested: Tested by IHC on formalin-fixed, paraffin-embedded human tissue using low pH antigen retrieval; optimal at ≤20 µg/mL.
Careful titration recommended for best assay performance.
Fluorophore Information:
eFluor® 660 is a replacement for Alexa Fluor® 647.
Emission: 659 nm | Excitation: 633 nm | Laser: Red Laser.
Ensure instrument compatibility.
Filtered post-manufacturing (0.2 µm).
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes oxidative cleavage of the indole ring of tryptophan, serotonin, and melatonin, initiating production of kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells.
Induced by interferons (IFNs), IDO1 plays a role in antimicrobial defense by depleting tryptophan, inhibiting growth of pathogens.
It also contributes to immune regulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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