Thermo Fisher Scientific HLA-DRB3 Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 Rabbit Polyclonal HLA-DRB3 항체. Western Blot, IHC, ICC/IF에 사용 가능. 합성 펩타이드 유래 면역원 기반, 고순도 친화 크로마토그래피 정제. PBS/glycerol 버퍼에 보관하며 -20°C 저장.
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Thermo Fisher Scientific HLA-DRB3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HLA-DRB3 (Accession P79483), corresponding to amino acid residues A78–V128 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851844 |
Product Specific Information
Antibody detects endogenous levels of total HLA-DRB3.
Target Information
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells are regulated by the dissociation of class II-associated invariant chain peptides (CLIP) and subsequent peptide antigen binding mediated by HLA-DM and -DO. These molecules accumulate in endosomal/lysosomal compartments and on B cell surfaces, facilitating peptide exchange for HLA class II molecules (HLA-DR, -DQ, -DP).
RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests certain polymorphisms may contribute to RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs, which play a central role in antigen presentation. HLA-B and -C form heterodimers with β2-microglobulin, and exhibit extensive polymorphism.
HLA and MHC antibodies are essential tools in Immunopeptidomics, aiding in the identification and characterization of neoantigens through LC-MS/MS analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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