Thermo Fisher Scientific KIR3DL1 Polyclonal Antibody
인간 KIR3DL1 단백질을 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 완충액에 보관되며, -20°C에서 보관 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIR3DL1 (Accession P43629), corresponding to amino acid residues F76–L126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851848 |
Product Specific Information
This antibody detects endogenous levels of total KIR3DL1.
Target Information
KIR3DL1 belongs to the Killer cell immunoglobulin-like receptor (KIR) family, which are transmembrane glycoproteins expressed by natural killer (NK) cells and subsets of T cells. KIR genes are polymorphic and located on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by the length of their cytoplasmic domain (L or S).
- Long (L) cytoplasmic domains contain ITIM motifs that transduce inhibitory signals.
- Short (S) cytoplasmic domains lack ITIM motifs and instead associate with TYRO protein tyrosine kinase binding protein to transmit activating signals.
Ligands for several KIR proteins are subsets of HLA class I molecules. KIRs play a crucial role in regulating immune responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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