Thermo Fisher Scientific MUTYH Polyclonal Antibody
Thermo Fisher Scientific의 MUTYH Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ICC/IF에 사용 가능. 합성 펩타이드 면역원 기반, 액상 형태로 -20°C 보관. DNA 손상 복구 연구에 적합.
- 카탈로그번호
- PA5102440
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MUTYH (Accession Q9UIF7), corresponding to amino acid residues L156–Q206 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851845 |
Product Specific Information
Antibody detects endogenous levels of total MUTYH.
Target Information
MYH (mutY homolog (E. coli)) is a DNA glycosylase mismatch repair enzyme that, in conjunction with mutM (OGG1), cleaves adenine residues paired with oxidized (8-hydroxyguanines) or non-modified guanines to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for avoiding mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation improve cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons, where mitochondrial genomes exposed to reactive oxygen species (ROS) must maintain integrity over the mammalian life span.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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