Thermo Fisher Scientific MUTYH Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MUTYH.

Target Information

MYH (mutY homolog (E. coli)) is a DNA glycosylase mismatch repair enzyme that, in conjunction with mutM (OGG1), cleaves adenine residues paired with oxidized (8-hydroxyguanines) or non-modified guanines to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for avoiding mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation improve cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons, where mitochondrial genomes exposed to reactive oxygen species (ROS) must maintain integrity over the mammalian life span.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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