Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI2G1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation and other cellular processes such as:

• Intracellular signaling cascades
• Protein phosphorylation
• Cell cycle control
• Chromatin modification
• DNA damage response

TLK2 activity peaks during the S phase of the cell cycle and is regulated by phosphorylation. It is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1.
This nuclear protein is widely expressed in fetal placenta, liver, kidney, pancreas, heart, skeletal muscle, and various adult cell lines.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.