Thermo Fisher Scientific ESRRB Monoclonal Antibody (OTI2F11), TrueMAB
Human ESRRB 단백질(아미노산 1-252)에 특이적인 Mouse IgG2b 단클론 항체. Western blot에 최적화된 TrueMAB 형식. Carrier-free 형태로 재구성 및 결합 실험에 적합. 줄기세포 자기재생 및 분화 관련 연구용.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–252 of human ESRRB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ESRRB (steroid hormone receptor ERR2) is involved in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through signaling pathways such as FGF and Wnt.
Upon activation of FGF signaling, ESRRB interacts with KDM1A, binding enhancer sites of ELF5 and EOMES, promoting transcription and self-renewal of trophoblast stem cells.
ESRRB also regulates rod-specific gene expression necessary for photoreceptor cell survival.
Mutations in ESRRB can lead to autosomal recessive deafness type 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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