Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI2F9), TrueMAB
TLK2 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, 무보존제 PBS buffer에 동결건조 형태로 제공. 재구성 및 결합 실험에 적합한 고순도 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–296 of human TLK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation.
It participates in intracellular signaling, protein phosphorylation, cell cycle regulation, chromatin modification, and DNA damage response.
TLK2 activity peaks during the S phase of the cell cycle and is regulated by phosphorylation.
Inhibition of DNA replication leads to rapid TLK2 inactivation, indicating its close link to DNA replication.
TLK2 forms heterodimers with TLK1 and is expressed in fetal placenta, liver, kidney, pancreas, heart, skeletal muscle, and various adult cell lines.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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