Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI2F9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain an antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation.
It participates in intracellular signaling, protein phosphorylation, cell cycle regulation, chromatin modification, and DNA damage response.
TLK2 activity peaks during the S phase of the cell cycle and is regulated by phosphorylation.
Inhibition of DNA replication leads to rapid TLK2 inactivation, indicating its close link to DNA replication.
TLK2 forms heterodimers with TLK1 and is expressed in fetal placenta, liver, kidney, pancreas, heart, skeletal muscle, and various adult cell lines.

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.