Thermo Fisher Scientific Phospho-p38 MAPK alpha (Thr180, Tyr182) Monoclonal Antibody (F.52.8)
p38 MAPK alpha의 Thr180/Tyr182 인산화 상태를 특이적으로 검출하는 rabbit monoclonal antibody. WB, IHC, ICC 등 다양한 응용 가능. 인간, 생쥐, 랫트 등 여러 종에 반응. 비교활성 없음, 액상 형태로 -20°C 보관.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-p38 MAPK alpha (Thr180, Tyr182) Monoclonal Antibody (F.52.8)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| ELISA | - | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Fruit fly, Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Zebrafish |
| Host/Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.52.8 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pThr180/Tyr182 of human p38 MAPK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 71 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10984205 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with the phosphorylated forms of either p42/44 MAPK or SAPK/JNK.
Target Information
MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs.
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals.
p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of Thr-Gly-Tyr motifs.
There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors.
Upon exposure to stimuli such as TNF, IL-1, or heat shock, MAPK kinase-3/6 phosphorylate Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK activates transcription factors including ATF-2, CHOP-1, and MEF-2 through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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