Thermo Fisher Scientific Phospho-p38 MAPK alpha (Thr180, Tyr182) Monoclonal Antibody (F.52.8)

Thermo Fisher Scientific Phospho-p38 MAPK alpha (Thr180, Tyr182) Monoclonal Antibody (F.52.8)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with the phosphorylated forms of either p42/44 MAPK or SAPK/JNK.

Target Information

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs.
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals.
p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of Thr-Gly-Tyr motifs.
There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors.
Upon exposure to stimuli such as TNF, IL-1, or heat shock, MAPK kinase-3/6 phosphorylate Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK activates transcription factors including ATF-2, CHOP-1, and MEF-2 through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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