Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI4C6), TrueMAB
인간 NUMB 단백질(aa 1-365)을 인식하는 Mouse IgG2a 단일클론 항체. Western blot에서 1:2,000 희석으로 검증됨. Lyophilized 형태로 제공되며, PBS 버퍼(8% trehalose) 보존. 신경세포 분화 및 엔도사이토시스 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–365 of human NUMB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step.
Suggested product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that regulates the differentiation of neuronal progenitor cells.
NUMB participates in clathrin-dependent endocytosis by binding to the AP-2 complex and is expressed in postmitotic neurons where it contributes to axonal growth.
Neural cells expressing NUMB isoforms with short phosphotyrosine-binding (SPTB) domains exhibit extensive neurite outgrowth, which can be blocked by VGCC inhibitors or Ca²⁺ chelators.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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