Thermo Fisher Scientific PARP1 (Cleaved Asp214) Polyclonal Antibody
Cleaved Asp214 부위를 인식하는 PARP1 폴리클로날 항체로, 인간·생쥐·랫드 시료에 반응합니다. Western blot에 최적화되어 있으며, apoptosis 과정에서 활성화된 PARP1 단편 검출에 유용합니다. 액상 형태로 -20°C 보관, Affinity chromatography로 정제됨.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PARP1 (Accession P09874), corresponding to amino acid residues P200–K222 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899322 |
Product Specific Information
Antibody detects endogenous levels of fragment of activated PARP resulting from cleavage adjacent to Asp214.
Target Information
Poly ADP-Ribose Polymerase (PARP) uses nicotinamide adenine dinucleotide (oxidized form, NAD) as a substrate to catalyze the transfer of ADP-ribose to nuclear protein acceptors. Proteolysis of PARP to its stable 85 kDa fragment is an early marker of apoptosis and is mediated by caspase CPP32. Cleavage occurs between Asp216 and Gly217, a site conserved across species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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