Thermo Fisher Scientific H2BK20ac Polyclonal Antibody
H2BK20ac Polyclonal Antibody는 인간, 생쥐, 랫트 시료에서 사용 가능한 Rabbit IgG 항체로, Lys20 위치에서 아세틸화된 H2B를 특이적으로 검출합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 최적화되어 있으며, 고순도 친화 크로마토그래피 정제 및 -20°C 보관 조건을 갖습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human H2BFS (Accession P57053), corresponding to amino acid residues A5–R32 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899328 |
Product Specific Information
This antibody detects endogenous levels of Acetyl-Histone H2B only when acetylated at Lys20.
Target Information
Histones are basic nuclear proteins responsible for the nucleosome structure of chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of the four core histones (H2A, H2B, H3, and H4). These nucleosomes further compact DNA into chromatin, limiting DNA accessibility to cellular machineries that require DNA as a template. Histones play a central role in transcription regulation, DNA repair, replication, and chromosomal stability. H2B also exhibits broad antibacterial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-114692_H2BK20ac_P57053-1_Rabbit.svg, PA5-114692_H2BK20ac_P57053-1_Rabbit_PDP.jpeg)
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