Thermo Fisher Scientific Caspase 3 (Cleaved Asp175) Polyclonal Antibody
Caspase 3 (Cleaved Asp175)에 특이적인 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF 등에 사용 가능. 인간, 마우스, 랫트 반응성. 활성화된 Caspase 3 절편 검출에 적합하며, 세포사멸 연구에 활용. PBS/glycerol buffer, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 12 publications |
| Immunohistochemistry (IHC) | – | View 7 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | View 1 publication |
| ELISA | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP3 (Accession P42574), corresponding to amino acid residues C163–M182. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899323 |
Product Specific Information
This antibody detects endogenous levels of the activated Caspase 3 fragment resulting from cleavage adjacent to Asp175.
Target Information
The CASP3 gene encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution phase of cell apoptosis. Caspases are synthesized as inactive proenzymes and activated by proteolytic cleavage at conserved aspartic residues, forming active dimers. Caspase 3 cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, linked to neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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