Thermo Fisher Scientific Acetyl-NFkB p65 (Lys310) Polyclonal Antibody
Acetyl-NFkB p65 (Lys310) 특이적 인식 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응. Western blot, IHC, ICC에 적합하며, 고순도 친화 크로마토그래피 정제. 액상 형태, 1 mg/mL 농도, -20°C 보관.
- 카탈로그번호
- PA599332
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RELA (Accession Q04206), corresponding to amino acid residues R295–S319. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | −20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818265 |
Product Specific Information
This antibody detects endogenous levels of Acetyl-NF-kappaB p65 only when acetylated at Lys310.
Target Information
Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and located on chromosome 11 in humans. NF-kB p65, also known as RelA, belongs to the Rel family of proteins. It forms heterodimers with subunits p50 or p52 to constitute NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells). Binding of TNF alpha to its receptor activates IKK, leading to phosphorylation and degradation of I kB, thus releasing NF-kB to translocate into the nucleus. NF-kB p65 plays a critical role in transcription of the immunoglobulin kappa gene in mature B-lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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