Thermo Fisher Scientific BACE2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human BACE2, validated for Western blot detection of ~70 kDa band in human heart tissue. Supplied unconjugated in liquid form at 1 mg/mL concentration. Suitable for research use in Alzheimer’s and APP processing stu...
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 44–59 of human BACE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070545 |
Product Specific Information
In Western blot, this antibody detects a ~70 kDa band in human heart tissue lysate.
Target Information
BACE2 (Beta Secretase 2) is responsible for the proteolytic processing of amyloid precursor protein (APP).
It cleaves APP between residues 690–691, leading to generation and extracellular release of beta-cleaved soluble APP.
BACE2 also cleaves APP between residues 671–672.
Accumulation of APP is a hallmark of Alzheimer’s disease and a frequent complication in adult Down syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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