Thermo Fisher Scientific BACE2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-1 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues 44-59 of human BACE2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BACE2,uniProtId:Q9Y5Z0-1,ncbiNodeId:9606,antigenRange:44-59,antigenLength:518,antigenImageFileName:PA1-12530_BACE2_Q9Y5Z0-1_Rabbit.svg,antigenImageFileNamePDP:PA1-12530_BACE2_Q9Y5Z0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1070545

Product Specific Information

In Western blot, this antibody detects a ~70 kDa band in human heart tissue lysate.

Target Information

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.