Thermo Fisher Scientific BACE1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

In Western blot, this antibody detects a ~70 kDa band in human brain lysate.

Target Information

BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer’s disease (AD). In some cases, early-onset familial AD can be attributed to a “Swedish” mutation in the amyloid precursor protein (APP), which enhances cleavage by BACE1. This has led to therapeutic approaches focused on inhibiting BACE1 and other APP-cleaving enzymes such as gamma-secretase. APP is first cleaved by beta-secretase, producing a soluble derivative and a membrane-anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment is then processed by gamma-secretase to generate the 4 kDa amyloid-beta peptide, which accumulates in the brains of Alzheimer’s disease patients. BACE1, also known as beta-site APP cleaving enzyme or Asp2, is a transmembrane aspartic protease that colocalizes with APP.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.