Thermo Fisher Scientific GFR alpha-1 Polyclonal Antibody
GFR alpha-1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC에 사용 가능하며, 인간 뇌 라이세이트를 양성 대조군으로 권장. -20°C에서 보관, 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 369–382 of human GFR alpha-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1074582 |
Product Specific Information
A suggested positive control for this product is human brain lysate.
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a novel glycosylphosphatidylinositol-linked protein, GDNFRalpha, which acts as a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken, and mouse have been cloned. GDNFRalpha, also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1), is now designated as GFR alpha-1.
GFR alpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Together, GDNF, GFR alpha-1, and Ret PTK form a complex that transduces the GDNF signal and mediates its biological function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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