Thermo Fisher Scientific AMPK alpha 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–8 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Pig and Orangutan

Target Information

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK).
AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits.
It acts as an energy-sensing enzyme that monitors cellular energy status.
In response to metabolic stress, AMPK becomes activated, phosphorylating and inactivating acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), key enzymes in fatty acid and cholesterol biosynthesis.
Mouse studies indicate that this catalytic subunit may regulate insulin sensitivity and maintain myocardial energy homeostasis during ischemia.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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