Thermo Fisher Scientific p70S6K Polyclonal Antibody
Rabbit polyclonal antibody targeting human p70S6K (RPS6KB1). Validated for Western blot with high dilution range. Predicted cross-reactivity with rat, bovine, and rabbit. Supplied as liquid, 1 mg/mL concentration, stored at 4°C.
- 카탈로그번호
- A300510Ax (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific p70S6K Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:2,500–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and the C-terminus (residue 525) of human Ribosomal Protein S6 Kinase, 70 kDa, polypeptide 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Rabbit
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein. It is predominantly localized in the cytoplasm and is essential in growth factor–regulated cell proliferation, pathways involving cell motility (such as metastases), immune response, and tissue repair.
p70S6K acts downstream of phosphoinositide (PI) 3-kinase, with its main physiological target being the S6 ribosomal protein involved in upregulation of protein synthesis. Its kinase activity leads to increased protein synthesis and cell proliferation. Amplification and overexpression of the p70S6K gene are observed in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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