Thermo Fisher Scientific Cytokeratin 14 (Squamous Cell Marker) Monoclonal Antibody (SPM263)
Cytokeratin 14 단백질을 인식하는 단클론 항체로, 상피세포 및 편평세포암 표지에 사용. 인체, 마우스, 랫트 반응성. IHC 및 ICC/IF에 적합. 단백질 A/G 정제, 액상 형태, 4°C 보관.
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Thermo Fisher Scientific Cytokeratin 14 (Squamous Cell Marker) Monoclonal Antibody (SPM263)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM263 |
| Immunogen | Synthetic peptide of 15 amino acids from the C-terminus of human keratin 14 (amino acids 457–472, UniProt ID: P02533-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokeratins (CK) are intermediate filaments found in epithelial cells, both keratinizing (e.g., skin) and non-keratinizing (e.g., mesothelial cells). At least 20 distinct CKs are known, categorized into type I (acidic polypeptides) and type II (basic polypeptides).
Keratin 14 belongs to the type I subfamily of low molecular weight keratins and pairs with keratin 5. It helps distinguish stratified epithelial cells from simple epithelial cells and serves as a useful marker for squamous cell carcinomas. Additionally, it is considered a prognostic marker in breast carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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