Thermo Fisher Scientific Cytokeratin 14 (KRT14) (Squamous Cell Marker) Monoclonal Antibody (rKRT14/7368)
인체 반응성의 Cytokeratin 14 단클론 항체로 편평상피세포 마커로 사용. 파라핀 및 PFA 고정 조직 IHC에 적용 가능. 단백질 A/G로 정제된 액상 형태, 4°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rKRT14/7368 |
| Immunogen | Recombinant human KRT14 fragment (around aa350–472) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (e.g., skin) and non-keratinizing cells (e.g., mesothelial cells). At least 20 different CKs can be identified. Most members of the CK family fall into one of two classes:
- Type I (acidic polypeptides)
- Type II (basic polypeptides)
Keratin 14 belongs to the type I subfamily of low molecular weight keratins and exists in combination with keratin 5. It distinguishes stratified epithelial cells from simple epithelial cells and is useful in identifying squamous cell carcinomas. It is also considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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