Thermo Fisher Scientific RUVBL2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: H1299
• Predicted reactivity:
  Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 93%
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity.
It is a component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes by acetylation of nucleosomal histones H4 and H2A.
This modification may alter nucleosome–DNA interactions and promote interaction of modified histones with other proteins that positively regulate transcription.
The NuA4 complex may be required for activation of transcriptional programs associated with oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair.
RUVBL2, together with RUVBL1 and EP400, contributes to the ATPase and helicase activities of the NuA4 complex.
It plays an essential role in oncogenic transformation by MYC and modulates transcriptional activation by the LEF1/TCF1–CTNNB1 complex, and may inhibit the transcriptional activity of ATF2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.