Thermo Fisher Scientific ACAT2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–2.5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

• Recommended positive controls: K562
• Predicted reactivity: Cow (79%), Dog (86%), Guinea Pig (79%), Horse (86%), Mouse (79%), Rat (79%), Yeast (82%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene represents a member of the frizzled gene family, which encodes 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.
The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif.
This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.