Thermo Fisher Scientific EpCAM (CD326) Monoclonal Antibody (323/A3), PE-Cyanine7
EpCAM(CD326) 단백질을 인식하는 마우스 모노클로날 항체로, PE-Cyanine7 형광으로 결합되어 세포표면 EpCAM 검출에 적합. 인간 시료 반응성, Flow Cytometry에 최적화. 암세포 및 상피세포 계통 연구용.
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Thermo Fisher Scientific EpCAM (CD326) Monoclonal Antibody (323/A3), PE-Cyanine7
Applications
- Flow Cytometry (Flow): 4 µL/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 323/A3 |
| Immunogen | Human breast cancer MCF-7 cells |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898630 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 647
- APC
- FITC
- PE
- PerCP-Cyanine5.5
- Custom conjugation available
Product Specific Information
This antibody recognizes an extracellular epitope of CD326 / EpCAM, a marker of epithelial lineages, that is over-expressed in many carcinomas.
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial cells. It functions as a calcium-independent homotypic cell adhesion molecule and influences cell cycle and proliferation through induction of proto-oncogene c-myc and cell cycle regulators cyclin A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for epithelial-lineage tumors.
Ep-CAM is found on the baso-lateral surface of most simple epithelia and many carcinoma types, and can distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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