Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), Biotin
CD8α 단백질을 인식하는 CT-8 클론의 Mouse IgG1 단클론 항체로 Biotin 결합형입니다. Flow Cytometry에 적합하며 Chicken 시료에서 반응합니다. 고순도 정제, 안정적 PBS buffer 보관, 연구용으로 T 세포 활성화 및 면역 반응 분석에 활용됩니다.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), Biotin
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-8 |
| Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745679 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a crucial role in signal transduction and T cell differentiation and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor for MHC class I molecules. CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Interaction with MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in clearing pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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