Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), Biotin

Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), Biotin

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 1 µg/10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• Cyanine5
• FITC
• PE
• PE-Cyanine5
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a crucial role in signal transduction and T cell differentiation and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor for MHC class I molecules. CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Interaction with MHC-I/peptide complexes triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in clearing pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.