Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (3-298), Biotin
CD8 alpha 단백질을 인식하는 Biotin 결합 단일클론 항체로, Flow Cytometry에 적합합니다. 닭(Chicken) 시료에 반응하며, 고순도 정제된 액상 형태로 제공됩니다. PBS 완충액에 안정화되어 있으며 연구용으로 사용됩니다.
- 카탈로그번호
- MA528719
- 판매단위
- pk
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Applications
- Flow Cytometry (Flow): 1 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3-298 |
| Immunogen | Chicken thymocytes |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.4, with proprietary stabilizer |
| Contains | <0.1% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745678 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential for T cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) acting as a co-receptor with TCR for MHC-I molecules, while CD4 interacts with MHC-II. CD8α is crucial for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers. Engagement of MHC-I/peptide complexes on antigen-presenting cells recruits Lck kinase, promoting lymphokine production, motility, and CTL activation. Activated CTLs are vital for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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