Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (3-298), Cyanine5

Applications

• Flow Cytometry (Flow): 1 µg/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (Cat. No. MA5-28728)
• Biotin (Cat. No. MA5-28719)
• FITC (Cat. No. MA5-28723)
• PE (Cat. No. MA5-28725)
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a critical role in signal transduction and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
CD8α is essential for binding to MHC-I and can also form homodimers expressed on subsets of T cells, NK cells, monocytes, and dendritic cells. Upon ligation with MHC-I/peptide complexes, CD8 recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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