Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11)

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• APC
• Biotin
• FITC
• PE
• PE-Cyanine5
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a crucial role in signal transduction, T cell differentiation, and activation. CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. In contrast, CD4 serves as a co-receptor for MHC class II molecules.

CD8α is essential for MHC-I binding and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Interaction of MHC-I/peptide complexes with CD8 triggers Lck recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are critical for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.