Thermo Fisher Scientific IFN gamma Polyclonal Antibody
인간 IFN gamma를 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 응용에 적합합니다. 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 재구성 시 500 µg/mL 농도이며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human IFN gamma recombinant protein (Position: Q24–Q166) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2884875 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, and cytokines. It is a dimeric glycoprotein composed of two 146 amino acid subunits with a molecular weight of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation. The biological activity of IFN gamma is species specific; human IFN gamma does not cross-react with mouse. Functions include antiviral and antiproliferative activities, induction of MHC class I/II, macrophage activation, and enhancement of immunoglobulin secretion by B lymphocytes. IFN gamma acts via IFN gamma receptor I and II, activating the JAK-STAT pathway. It shares about 40% sequence homology with mouse IFN gamma and is regulated by IL2, FGF basic, EGF, and downregulated by vitamin D3 or DMN. Mutations in the IFN gamma gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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