Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (rMAC3781)
Calprotectin(MRP14/S100A9/Calgranulin B) 단일클론 항체로 다양한 종에서 반응하며, IHC(PFA 및 Paraffin)에 사용 가능. 단백질 A/G 정제, 액상 형태, 200 µg/mL 농도. 염증성 질환 연구용으로 적합하며, 4°C 보관.
- 카탈로그번호
- 6279-MSM6-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (rMAC3781)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Cat, Guinea pig, Goat, Human, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rMAC3781 |
| Immunogen | Affinity purified monocyte membrane preparation (Calprotectin, UniProt IDs: P06702-1, P05109-1, antigen range 1–114 and 1–93) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The S100A8/A9 heterocomplex, also known as MRP-8/MRP-14 complex or calprotectin, comprises approximately 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes carry the antigen both extra- and intracellularly, whereas neutrophils carry it only intracellularly.
The S100A8/A9 complex exhibits antibacterial, antifungal, immunomodulating, and antiproliferative effects and acts as a potent chemotactic factor for neutrophils.
Plasma concentrations are elevated in diseases associated with increased neutrophil activity, such as inflammatory bowel disease.
Calprotectin is detectable in feces due to granulocyte transmigration through the intestinal wall. Elevated levels have been observed in plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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