Thermo Fisher Scientific FGFR1 Monoclonal Antibody (OTI5D5), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL antibody concentration.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

FGFR1 (also known as FLT2) belongs to the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases acting as high-affinity receptors for 17 growth factors (FGF1–17).
FGFR1 plays a crucial role in mesoderm induction, patterning, cell growth and migration, organ formation, and bone development.
Alternative splicing generates multiple variants expressed differently during embryonic development and in adults.
Mutations or aberrations in FGFR1 are linked to several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal rearrangements involving FGFR1 are associated with stem cell myeloproliferative disorders and stem cell leukemia/lymphoma syndromes.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.