Thermo Fisher Scientific RIPK3 Monoclonal Antibody (OTI2B10), TrueMAB
인간 RIPK3 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 IHC(파라핀)에서 검증됨. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. 세포사멸 및 신호전달 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 233–518 of human RIPK3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, containing a unique C-terminal domain. It is predominantly localized in the cytoplasm and mitochondria, capable of nucleocytoplasmic shuttling.
RIPK3 participates in the TNF receptor-I signaling complex and can induce apoptosis and weakly activate NF-κB. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, which is essential for its protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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