Thermo Fisher Scientific KBTBD3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
IMDAIKCVQG SGGLFPDARP STTEKYIFIH KTEENGENQY TFCYNIKSDS WKILPQSHLI DLPGSSLSSY GEKIFLTGGC KGKCCRTVRL HIAESYHDAT DQTWCY

• Highest antigen sequence identity to orthologs:
  • Mouse: 94%
  • Rat: 94%

Target Information

The BTB (Broad-Complex, Tram track and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers.
Proteins containing BTB domains are involved in transcriptional regulation via control of chromatin structure and function.

KBTBD3 (kelch repeat and BTB domain-containing protein 3), also known as BKLHD3, is a 608 amino acid protein containing:

• One BACK (BTB/Kelch associated) domain
• One BTB (POZ) domain
• Five kelch repeats

The gene encoding KBTBD3 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.
Chromosome 11 is associated with genetic disorders such as Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.