Thermo Fisher Scientific Phospho-Tropomyosin-1 alpha (Ser283) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

Anti-Tropomyosin-1 alpha pS283 is directed against the phosphorylated form of human S283 residue. A BLAST analysis suggests cross-reactivity with mouse and human based on 100% sequence homology. Cross-reactivity with Tropomyosin-1 alpha pS283 from other sources has not been determined.

Target Information

Tropomyosin is a dimeric coiled-coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified by their different apparent molecular masses after SDS-PAGE separation but similar biochemical properties such as resistance to heat and organic solvents, ability to bind F-actin filaments, and lack of proline and tryptophan.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.