Thermo Fisher Scientific STIM2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

A BLAST analysis was used to suggest cross-reactivity with mouse and human based on 100% sequence homology. Cross-reactivity with Stim II from other sources has not been determined.

Target Information

In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels consist of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels by migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites, which act as the Ca++ store.
A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry and can form complexes with STIM1, suggesting a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.