Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (3-298), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 0.2 µg/10^6 cells
• View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• Cyanine5
• FITC
• Custom conjugation available

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in signal transduction, T cell differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC-I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes on antigen-presenting cells recruits Lck kinase, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance, and their differentiation is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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