Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (3-298), PE
CD8α 단백질을 인식하는 마우스 모노클로날 항체로, PE 형광표지되어 Flow Cytometry에 적합. 치킨 및 조류 시료 반응성. 고순도 정제, 4°C 암소 보관. 다양한 형광 및 비표지 포맷 제공.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 0.2 µg/10^6 cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Published Species | Chicken |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3-298 |
| Immunogen | Chicken thymocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.5 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745684 |
Additional Formats
- Unconjugated
- Biotin
- Cyanine5
- FITC
- Custom conjugation available
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in signal transduction, T cell differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC-I molecules.
It is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers.
Engagement of MHC-I/peptide complexes on antigen-presenting cells recruits Lck kinase, leading to lymphokine production and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance, and their differentiation is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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