Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), Cyanine5
Cyanine5 형광으로 표지된 CD8 alpha 단클론 항체로, 조류(특히 닭) CD8 검출에 적합합니다. Flow Cytometry에 최적화되어 있으며, 고순도 정제된 액상 형태로 제공됩니다. 4°C 암소 보관, 연구용 전용 제품입니다.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (CT-8), Cyanine5
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.2 µg/10^6 cells
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT-8 |
| Immunogen | Chicken thymocytes and Ig-negative blood leukocytes |
| Conjugate | Cyanine5 |
| Excitation / Emission Max | 647 / 665 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4, with proprietary stabilizer |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745681 |
Additional Formats
- Unconjugated (MA5-28729)
- APC (MA5-28718)
- Biotin (MA5-28720)
- FITC (MA5-28724)
- PE (MA5-28726)
- PE-Cyanine5 (MA5-28727)
- Request custom conjugation (Thermo Fisher form)
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family, essential for T cell signal transduction, differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β), acting as a co-receptor with TCR for MHC-I molecules.
CD8α also forms homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells.
Upon MHC-I/peptide complex ligation, CD8 recruits Lck kinase, inducing lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor clearance.
Naive CD8+ T cell differentiation into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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