Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (3-298), FITC
FITC 형광 표지된 CD8 alpha 단클론 항체로, 조류(특히 닭) 세포 표면 CD8 검출에 적합. Flow Cytometry에서 1 µg/10^6 cells로 사용 가능. 고순도 정제된 액상 형태로 4°C 암소 보관. 연구용으로만 사용.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3-298 |
| Immunogen | Chicken thymocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage conditions | 4°C, store in dark |
| RRID | AB_2745682 |
Additional Formats
- Unconjugated
- Biotin
- Cyanine5
- PE
- Custom conjugation available
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in T cell signal transduction, differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC-I molecules. CD8α also forms homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte activation. Activated CTLs are essential for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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